NIH-National Institute of General Medical Sciences

Core C: Library Design, Analysis & Purification

The Core C is responsible for the characterization of the libraries synthesized with respect to identity and purity. The LDAP Core also handles informatics issues and provides computational assistance to scientists designing libraries with an eye to downstream biological collaborations.


The Library Design, Analysis and Purification Core Laboratory (LDAP Laboratory, Core C) is responsible for assisting with the design of diverse libraries and carrying out the spectroscopic characterization of library members. The main activities of the LDAP core laboratory are as follows:

1.     The LDAP core laboratory provides the research projects and synthesis core laboratory with the computational resources for managing chemical structures and data, predicts key physicochemical properties of compounds to be synthesized, and provides guidance in the design of diverse libraries. 

2.     The LDAP core laboratory delivers automated, high throughput mass spectrometry and NMR analyses for confirming the identity and purity of compounds in libraries.

View a PowerPoint presentation (.ppt) on KU CMLD Core C.



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