NIH-National Institute of General Medical Sciences


Goodell, J.R.; Poole, J.L.; Beeler, A.B.; Aubé, J.; Porco, Jr., J.A. Synthesis and Reactivity of Bicyclo[3.2.1]octanoid-Derived Cyclopropanes. J Org Chem 2011, 76, 9792-9800. Online access to the article.

Organ, M. G.; Hanson, P. R.; Rolfe, A.; Samarakoon, T. B.; Ullah, F. Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out. J. Flow Chem., 2011, 1, 32–39. Thematic Issue on Flow. Online access to the article.

Zang, Q.; Javed, S.; Ullah, F.; Zhou, A.; Knudtson, C. A.; Bi, D.; Basha, F. Z.; Organ, M. G.; Hanson, P. R. Application of a Double aza-Michael Reaction in a "Click, Click, Cy-Click" Strategy: From Bench to Flow. Synthesis, 2011, 2743–2750. Thematic Issue on Click Chemistry. Online access to the article.

Zhang, J.; Lushington G.H.; Huan J. Characterizing the diversity and biological relevance of the MLPCN assay manifold and screening set. J Chem Inf Model 2011, 51(6), 1205-1215.Online access to the article.

Zhang, J.; Lushington G.H.; Huan J. The BioAssay network and its implications to future therapeutic discovery. BMC Bioinformatics 2011, 12(Suppl 5), S1. Online access to the article.

Maity, P.K.; Kainz, Q.M.; Faisal, S.; Rolfe, A.; Samarakoon, T.B.; Basha, F.Z.; Reiser, O.; Hanson, P. R. Intramolecular Monomer-on-Monomer (MoM) Mitsunobu Cyclization for the Synthesis of Thiadiazepine-dioxides. Chem. Commun. 2011, 47, 12524-12526. Online access to the article.

Dubrovskiy, A.V.; Larock, R.C. Synthesis of o-(Dimethylamino)aryl Ketones and Acridones by the Reaction of 1,1-Dialkylhydrazones and Arynes. Org Lett 2011, 13, 4136-4139. Online access to the article.

Rogness, D.C.; Larock, R.C. Synthesis of N-Arylisatins by the Reaction of Arynes with Methyl 2-Oxo-2-(arylamino)acetates. J Org Chem 2011, 76, 4980-4986. Online access to the article.

Rolfe, A.; Ullah, F.; Samarakoon, T.B.; Kurtz, R.D.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Santini, C.; Organ, M.G.; Hanson, P.R. Synthesis of Amino-Benzothiaoxazepine-1,1-dioxides Utilizing a Microwave-Assisted, SNAr Protocol. ACS Combi. Sci. 2011, 13, 653-658. Online access to the article.

Thornton, P. D.; Brown, N.; Hill, D.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Buszek, K. R. Application of 6,7-Indole Aryne Cycloaddition and Pd(0)-Catalyzed Suzuki-Miyaura and Buchwald-Hartwig Cross-Coupling Reactions for the Preparation of Annulated Indole Libraries. ACS Comb. Sci. 2011, 13, 443-448. Online access to the article.

Kumar, S.; Painter, T. O.; Benoy, K. P.; Neuenswander, B.; Malinakova, H. C. Application of Sequential Cu(I)/Pd(0)-Catalysis to Solution-Phase Parallel Synthesis of Combinatorial Libraries of Dihydroindeno[1,2-c]isoquinolines. ACS Comb. Sci. 2011, 13, 466-477. Online access to the article.

Rolfe, A.; Ullah, F.; Samarakoon , T. B.; Kurtz, R. D.; Porubsky, P.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Organ, M. G.; Hanson, P. R. Microwave-Assisted SNAr diversification of MACOS-derived Amino-Benzothiaoxazepine-1,1-dioxides. ACS J. Comb. Sci. 2011, 13, (online). Online access to the article.

Cho, C.-H.; Jung, D.-I.; Neuenswander, B.; Larock, R.C. Parallel Synthesis of a Desketoraloxifene Analog Library via Iodocyclization/Palladium-Catalyzed Coupling. ACS Comb. Sci. 2011 , 13, 501-510. Online access to the article.

Samarakoon, T.B.; Loh, J.K.; Rolfe, A.; Le, L.S.; Yoon, S.Y.; Lushington, G.H.; Hanson, P.R. A Modular Reaction Pairing Approach to the Diversity-Oriented Synthesis of Fused- and Bridged-Polycyclic Sultams. Org. Lett. 2011, 13(19), 5148-5151. Online access to the article.

Rolfe, A.; Painter, T.O.; Asad, N.; Hur, M.Y.; Jeon, K.O.; Brzozowski, M.; Klimberg, S.V.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Santini, C.; Hanson, P.R. Triazole-Containing Isothiazolidine 1,1-Dioxide Library Synthesis: One- Pot, Multi-Component Protocols for Small Molecular Probe Discovery. ACS Comb. Sci. 2011, 13, 511-517. Online access to the article.

Painter, T.O.; Thornton, P.D.; Orestano, M.; Santini, C.; Organ, M.G.; Aubé, J. In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format. Chem. Eur. J. 2011, 17, 9595-9598. Online access to the article.

Asad, N.; Hanson, P.R.; Long, T.R.; Rayabarapu, D.K.; Rolfe, A. Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol. Chem. Commun. 2011, 47, 9528-9530. Online access to the article.

Coombs, T.C.; Lushington, G.H.; Douglas, J.; Aubé, J. 1,3-Allylic Strain as a Strategic Diversification Element for Constructing Libraries of Substituted 2-Arylpiperidines. Angewandte Chemie, International Edition 2011, 50(12), 2734-2737. Online access to the article.

Ghosh, P.; Aubé, J. Resolution of Carboxylic Acids Using Copper (I)-Promoted Removal of Propargylic Esters Under Neutral Conditions. J Org. Chem. 2011, 76, 4168-4172. Online access to the article.

Huh, C.W.; Schroeder, C.; Singh, G.; Aubé, J. Stereoselectivity in Nucleophilic Additions to 3-Azidoalkanals. J. Org. Chem. 2011 76, 3160-3165. Online access to the article.

Fenster, E.; Fehl, C.; Aubé, J. Use of a Tandem Prins/Friedel-Crafts Reaction in the Construction of the Indeno-Tetrahydropyridine Core of the Haouamine Alkaloids: Formal Synthesis of (-)-Haouamine A." Org. Lett. 2011, 13(10), 2614-2617. Online access to the article.

Long, T. R.; Faisal, S.; Maity, P. K.; Rolfe, A.; Kurtz, R.; Klimberg, S. K.; Najjar, R.; Basha, F.; Hanson, P. R. “Click”-Capture, Ring-Opening Metathesis Polymerization (ROMP), Release: Facile Triazolation Utilizing ROMP-Derived Oligomeric Phosphates. Org. Lett. 2011, 13, 2038-2041. Online access to the article.

Ehlers, I.; Maity, P.; Aube, J.; Konig, B. Modular Synthesis of Triazole-Containing Triaryl Alpha-Helix Mimetics. Eur. J. Org. Chem. 2011, 13, 2474-2490. Online access to the article.

Frankowski, Kevin J.; Setola, Vincent; Evans, Jon M.; Neuenswander Ben; Roth, Bryan L.; Aube, Jeffrey. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class fo sigma ligands. PNAS 2011, 108(17), 6727-6732. Online access to the article.

Maity, Pradip K.; Rolfe, Alan; Samarakoon, Thiwanka B.; Faisal, Saquib; Kurtz, Ryan D.; Long, Toby, R.; Schtz, Alexander; Flynn, Daniel L.; Grass, Robert N.; Stark, Wendelin J.; Reiser, Oliver; and Hanson, Paul R. Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration. Org. Lett. 2011, 13(1), 8-10. Online access to the article.

Rolfe, Alan; Loh, Joanna K.; Maity, Pradip K.; and Hanson, Paul R. High-Load, Hybrid Si-ROMP Reagents. Org. Lett. 2011, 13(1), 4-7. Online access to the article.

Cho, C.-H.; Larock, R. C. Highly Substituted Lactone/Ester-Containing Furan Library by the Palladium-Catalyzed Carbonylation of Hydroxyl-Substituted 3-Iodofurans. ACS Comb. Sci. 2011, 13, 272-279. Online access to the article.

Markina, N., Mancuso, R., Neuenswander, B., Lushington, G., Larock, R. Solution-Phase Parallel Synthesis of a Diverse Library of 1,2-Dihydroisoquinolines. ACS Comb. Sci. 2011, 13, 265-271. Online access to the article.

Fenster, E.; Long, T.; Zang, Q.; Hill, D.; Neuenswander, B.; Lushington, G.H.; Zhao, A.; Santini, C.; Hanson, P. Automated Synthesis of a 184-Member Library of Thiadiazepan-1,1-dioxide-4-ones. ACS Comb. Sci.2011, 13, 244-250. Online access to the article.

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