NIH-National Institute of General Medical Sciences


Achanta, S.; Liautard, V.; Paugh, R.; Organ, M.G. The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products Using Continuous Flow Techniques. Chem. Eur. J. 2010, 16(43), 12797-12800. Online access to the article.

Schätz, A.; Long, T. R.; Grass, R. N.; Stark, W. J.; Hanson, P. R.; Reiser, O. Immobilization on a Nanomagnetic Co/C Surface using ROM Polymerization: Generation of a Novel Hybrid Material as Support for a Recyclable Palladium Catalyst. Adv. Func. Mat., 2010, 20, 4323–4328. Online access to the article.

Kivrak, A.; Larock, R. C. Synthesis of Dihydrobenzisoxazoles by the [3+2] Cycloaddition of Arynes and Oxaziridines. J. Org. Chem. 2010, 75, 7381-7387. Online access to the article.

Rolfe, A.; Samarakoon, T. B.; Klimberg, S. V.; Brzozowski, M.; Neuenswander, B.; Lushington, G. H.; Hanson, P. R. SNAr-Based, Facile Synthesis of a Library of Benzothiaoxazepine-1,1?-dioxides. J. Comb. Chem. 2010, 12(6), 850-854. Online access to the article.

Ullah, F.; Samarakoon, T.; Rolfe, A.; Kurtz, R. D.; Hanson, P. R.; Organ, M. G. Scaling Out by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): Multi-Gram Synthesis of Bromo- and Fluoro-benzofused Sultams Benzthiaoxazepine-1,1-dioxides. Chem. Eur. J. 2010, 16(36), 10959-10962. Online access to the article.

Dubrovskiy, A. V.; Larock, R. C. Intermolecular C-O addition of carboxylic acids to arynes. Org. Lett. 2010, 12(14), 3117-3119. Online access to the article.

Torregrosa, R. R. P.; Ariyarathna, Y.; Chattopadhyay, K.; Tunge, J. A. Decarboxylative Benzylations of Alkynes and Ketones. J. Am. Chem. Soc. 2010, 132(27), 9280-9282. Online access to the article.

Chattopadhyay, K.; Jana, R.; Day, V. W.; Douglas, J. T.; Tunge, Jon A. Mechanistic Origin of the Stereodivergence in Decarboxylative Allylation. Org. Lett. 2010, 12(13), 3042-3045.Online access to the article.

Smalter, A.; Huan,J.; Jia, Y.; Lushington, G.H. GPD: A Graph Pattern Diffusion Kernel for Accurate Graph Classification with Applications in Cheminformatics. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2010, 7, 197-207. Online access to the article.

Cho, C.-H.; Larock, R. C. A Convenient Synthetic Route to Furan Esters and Lactones by Palladium-Catalyzed Carboalkoxylation or Cyclocarbonylation of Hydroxyl-Substituted 3-Iodofurans. Tet. Lett. 2010, 51, 3417-3421. Online access to the article.

Cho, C.-H.; Jung, D.-I.; Larock, R. C. A New Approach to Desketoraloxifene Analogs from Oxygen-bearing 3-Iodobenzo[b]thiophenes Prepared via Iodocyclization. Tet. Lett. 2010, 51, 6485-6488. Online access to the article.

Long, T. R.; Maity, P. K.; Samarakoon, T. B. and Hanson, P. R. ROMP-Derived Oligomeric Phosphates for Application in Facile Benzylation. Org. Lett. 2010, 12(13), 2904-2907. Online access to the article.

Frankowski, K. J.; Ghosh, P.; Setola, V.; Tran, T. B.; Roth, B. L. and Aubé, J. N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic Kappa-Opioid Receptor Ligands. ACS Med. Chem. Lett. 2010, 1(5), 189-193. Online access to the article.

Wu, C.; Fang, Y.; Larock, R. C.; Shi, F. Synthesis of 2H-Indazoles by the [3+2] Cycloaddition of Arynes and Sydnones. Org. Lett. 2010, 12, 2234-2237. Online access to the article.

Samarakoon, T. B.; Hur, M. Y.; Kurtz, R. D.; Hanson, P. R. A Formal [4+4] Complementary Ambiphile Pairing (CAP) Reaction: A New Cyclization Pathway for ortho-Quinone Methides. Org. Lett. 2010, 2182-2185. Online access to the article.

Treece, J. L.; Goodell, J. R.; Vander Velde, D.; Porco, Jr., J. A.; and Aubé, J. Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers. J. Org. Chem. 2010, 75, 2028-2038. Online access to the article.

Mehta, S.; Larock, R. C. Iodine/Palladium Approaches to the Synthesis of Polyheterocyclic Compounds. J. Org. Chem. 2010, 75, 1652-1658. Online access to the article.

Dubrovskiy, A. V.; Larock, R. C. Synthesis of Benzisoxazoles by the [3+2] Cycloaddition of in situ Generated Nitrile Oxides and Arynes. Org. Lett. 2010, 12, 1180-1183. Online access to the article.

Rolfe, A.; Lushington, G. H.; Hanson, P. R. Reagent based DOS: A Click, Click, Cyclize strategy to probe chemical space. Org. Biomol. Chem. 2010, 8, 2198-2203. Online access to the article.

Rogness, D. C.; Larock, R. C. Synthesis of Acridines by the [4+2] Annulation of Arynes and 2-Aminoaryl Ketones. J. Org. Chem. 2010, 75, 2289-2295. Online access to the article.

Rolfe, A.; Samarakoon, T. B.; Hanson, P. R. Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy. Org. Lett. 2010, 12, 1216-1219. Online access to the article.

Garr, A. N.; Luo, D.; Brown, N.; Cramer, C. J.; Buszek, K. R.; VanderVelde, D. Experimental and Theoretical Investigations into the Unusual Regioselectivity of 4,5-, 5,6-, and 6,7-Indole Aryne Cycloadditions. Org. Lett. 2010, 12(1), 96-99. Online access to the article.

Cho, C.-H., Neuenswander, B., Larock, R.C. Diverse Methyl Sulfone-Containing Benzo[b]thiophene Library via Iodocyclization and Palladium-Catalyzed Coupling. J. Comb. Chem. 2010, 12(2), 278-285. Online access to the article.

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