NIH-National Institute of General Medical Sciences


Wang, C.; Pahadi, N.; Tunge, J. A. Decarboxylative cyclizations and cycloadditions of palladium-polarized aza-ortho-xylylenes. Tetrahedron 2009, 65, 5102-5109. Online access to the article.

Xiaohong W., Smalter, A., Huan, J., Lushington, G. H. G-Hash: Towards Fast Kernel-based Similarity Search in Large Graph Databases. Proceedings of the 12th International Conference on Extending Database Technology (EDBT'09) 2009, 472-480. Online access to the article.

Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; and Tunge, J. A. Formation of N-alkylpyrroles via intermolecular redox amination. J. Am. Chem. Soc. 2009, 131, 16626-16627. Online access to the article.

Jeon, K.; Rayabarapu, D.; Rolfe, A.; Volp, K.; Omar, I.; Hanson, P. R. Metathesis Cascade Strategies (ROM-RCM-CM): A DOS Approach to Skeletally Diverse Sultams. Tetrahedron 2009, 65, 4992-5000. Online access to the article.

Smalter, A.; Huan, J.; Lushington, G. Graph Wavelet Alignment Kernels for Drug Virtual Screening. J. Bioinform. Comput. Biol. 2009, 7, 473-497. Online access to the article.

Brown, N.; Luo, D.; Decapo, J. A.; Buszek, K. R. New Synthesis of (±)-Cis-Trikentrin A via Tandem Indole Aryne Cycloaddition/Negishi Reaction. Applications to Library Development. Tetrahedron Lett. 2009, 50(51), 7113-7115. Online access to the article.

Rolfe, A.; Hanson, P. R. Microwave-assisted Sequential One-pot Protocol to Benzothiadiazin-3-one-1,1-dioxides via a Copper-catalyzed N-Arylation Strategy. Tetrahedron Lett. 2009, 50(50), 6935-3937. Online access to the article.

Worlikar, S. A.; Larock, R. C. Synthesis of 9-Fluorenylidenes and 9,10-Phenanthrenes through Palladium-catalyzed Aryne Annulation by o-Halostyrenes and o-Halo Allylic Benzenes. J. Org. Chem. 2009, 74, 9132-9139. Online access to the article.

Perchellet, J-P.H.; Perchellet, E.M.; Crow, K.R.; Buszek, K.R.; Brown, N.; Ellappan, S.; Gao, G.; Luo, D.; Minatoya, M.; Lushington, G.H. Novel Synthetic Inhibitors of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Activity that Inhibit Tumor Cell Proliferation and are Structurally Unrelated to Existing Statins. Int. J. Mol. Med. 2009, 24(5), 633-643. (Cover Article) Online access to the article.

Ward, T.R.; Turunen, B.J.; Haack, T.; Neuenswander, B.; Shadrick, W.; Georg, G.I. Synthesis of a quinolone library from ynones. Tetrahedron Lett. 2009, 50(47), 6494-6497. Online access to the article.

Chen, Y.; Cho, C.-H.; Shi, F.; Larock, R. C. Synthesis of 3-Sulfenyl- and 3-Selenylindoles by the Pd/Cu-Catalyzed Coupling of N,N-Dialkyl-2-iodoanilines and Terminal Alkynes, Followed by n-Bu4NI-Induced Electrophilic Cyclization. J. Org. Chem. 2009, 74, 6802-6811. Online access to the article.

Jana, R.; Trivedi, R.; Tunge, J. A. Mild Decarboxylative Allylation of Coumarins. Org. Lett. 2009, 11(15), 3434-3436. Online access to the article.

Duan, S.; Jana, R.; Tunge, J. A. Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters. J. Org. Chem. 2009, 74(12), 4612-4614. Online access to the article.

Chen, Y.; Markina, N. A.; Larock, R. C. An Efficient, Microwave-Assisted, One-Pot Synthesis of Indoles Under Sonogashira Conditions. Tetrahedron 2009, 65, 8908-8915. Online access to the article.

Shi, F; Mancuso, R.; Larock, R. C. 1,3-Dipolar Cycloaddition of Arynes with Azomethine Imines: Synthesis of 1,2-Dihydropyrazolo[1,2-a]indazol-3(9H)-ones. Tetrahedron Lett. 2009, 50, 4067-4070. Online access to the article.

Rogness, D.; Larock, R. C. Rapid Synthesis of the Indole-Indolone Scaffold via [3+2] Annulation of Arynes by Methyl Indole-2-carboxylates. Tetrahedron Lett. 2009 , 50, 4003-4008. Online access to the article.

Worlikar, S. A.; Larock, R. C. Palladium-Catalyzed Synthesis of 9-Fluorenylidenes through Aryne Annulation. Org. Lett. 2009, 11(11), 2413-2416. Online access to the article.

Cho, C. H.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Solution-Phase Parallel Synthesis of a Multi-substituted Benzo[b]thiophene Library. J. Comb. Chem. 2009, 11, 900-906. Online access to the article.

Worlikar, S. A.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Highly Substituted Indole Library Synthesis by Palladium-Catalyzed Coupling Reactions in Solution and on a Solid Support. J. Comb. Chem. 2009, 11, 875-879. Online access to the article.

Hershberger, J. C.; Day V. W.; Malinakova, H. C. Diastereoinduction in the Synthesis of Pallada(II)pyrrolidinones: Palladacycles with Two Pd-bonded Stereogenic Carbons. Organometallics 2009, 28(3), 810–818. Online access to the article.

Rolfe, A.; Young, K.; Volp, K.; Schoenen, F. J.; Neuenswander, B.; Lushington, G. H.; Hanson, P. R. One-Pot, Three-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1, 2-benzisothiazoline-3-acetic Acids. J. Comb. Chem. 2009, 11(4), 732-738. Online access to the article.

Rayabarapu, D. K.; Zhou, A.; Jeon, K. O.; Samarakoon, T.; Rolfe, A.; Siddiqui, H.; Hanson, P. R. a-Haloarylsulfonamides: Multiple Cyclization Pathways to Skeletally Diverse Benzofused Sultams. Tetrahedron 2009, 65(16), 3180-3188. Online access to the article.

Thiruvellore, T. J.; Lei, Z.; Johnson, T. S.; Malinakova, H. C. Sequential Cu(I)/Pd(0)-Catalyzed Multicomponent Coupling and Annulation Protocol for the Synthesis of Indenoisoquinolines. Org. Lett. 2009, 11(4), 815-818. Online access to the article.

Zhou, A.; Rayabarapu, D.; Hanson, P. R. Click, Click, Cyclize: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchpins. Org. Lett. 2009, 11(3), 531-534. Online access to the article.

Verma, A. K.; Kesharwani, T.; Singh, J.; Tandon, V.; Larock, R. C. A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines. Angew. Chem, Int. Ed. 2009, 48(6), 1138-1143. Online access to the article.

Mehta, S.; Waldo, J. P.; Larock, R. C. Competition Studies in Alkyne Electrophilic Cyclization Reactions. J. Org. Chem. 2009, 74(3), 1141-1147. Online access to the article.

Buszek, K. R.; Brown, N.; Luo, D. Concise Total Synthesis of (±)-cis-Trikentrin A and (±)-Herbindole A via Intermolecular Indole Aryne Cycloaddition. Org. Lett. 2009, 11(1), 201-204. Online access to the article.

Chen, Y.; Cho, C. H.; Larock, R. C. A Novel Synthetic Route to 3-Sulfenyl- and 3-Selenylindoles by n-Bu4NI-Induced Electrophilic Cyclization. Org. Lett. 2009, 11(1), 173-176. Online access to the article.

Brown, N.; Luo, D.; VanderVelde, D.; Yang, S.; Brassfield, A.; Buszek, K. R. Regioselective Diels-Alder Cycloadditions and Other Reactions of 4,5-, 5,6-, and 6,7-Indole Arynes. Tetrahedron Lett. 2009, 50(1), 63-65. (Cover Article on the 50th Anniversary Cover) Online access to the article.

Roy, S., Roy, S., Neuenswander, B., Hill, D., Larock, R.C. Solution-Phase Synthesis of a Diverse Isocoumarin Library. J. Comb. Chem. 2009 11(6), 1128-1135. Online access to the article.

Roy, S., Roy, S., Neuenswander, B., Hill, D., Larock, R.C. Palladium- and Copper-Catalyzed Solution Phase Synthesis of a Diverse Library of Isoquinolines. J. Comb. Chem. 2009 11(6), 1061-1065. Online access to the article.

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