NIH-National Institute of General Medical Sciences

Publications-All

2014

Painter, T.P.; Kaszas, K.; Gross, J.; Douglas, J.T.; Day, V.W.; Iadarola, M.J.; Santini, C. Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides.  Bioorg. & Med. Chem. Lttrs2014, 24, 963-968.   Online access to the article.

Jessamyn I. Perlmutter, Lauren T. Forbes,Damian J. Krysan, Katherine Ebsworth-Mojica, Jennifer M. Colquhoun, Jenna L. Wang, Paul M. Dunman, and Daniel P. Flaherty. Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus. Journal of Medicinal Chemistry, 2014, 57(20), 8540-8562.  Online Access to the Article

Perchellet, J-P. H; Perchellet, E.M.; Singh, C.R.; Monnett, M.T.; Studer, E.R.; Thornton, P. D.; Brown, N.; Hill, D.; Neuenswander, B.; Lushington, G.H.; Santini, C.; Buszek, K.R.  Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro.  Anticancer Research, 2014, 34, 1643-1656.

2013

Painter, T.P.; Kaszas, K.; Gross, J.; Douglas, J.T.; Day, V.W.; Iadarola, M.J.; Santini, C. Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides.  Bioorg. & Med. Chem. Lttrs, 2014, 24, 963-968.   Online access to the article.

Kumar, S.; Thornton, P.D.; Santini, C. Diversity by Divergence: Solution Phase Parallel Synthesis of a Library of N-Diversified 1-Oxa-7-Azaspiro[4.5]decan-2-yl-Propanes and -Butanes. ACS Comb. Sci. 2013, 15(11), 564-571. Online access to the article.

Kumar, S.; Thornton, P.D.; Painter, T.O.; Jain, P.; Downard, J.; Douglas, J.T.; Santini, C. Synthesis of a Family of Spirocyclic Scaffolds; Building Blocks for the Exploration of Chemical Space. J. Org. Chem. 2013, 78(13), 6529-6539. Online access to the article.

Painter, T.O.; Bunn, J.R.; Schoenen, F.J.; Douglas, J.T.; Day, V.W.; Santini, C. Skeletal Diversification via Heteroatom Linkage Control: Preparation of Bicyclic and Spirocyclic Scaffolds from N-Substituted Homopropargyl Alcohols. J. Org. Chem.2013, 78(8), 3720-3730. Online access to the article.

Dubrovskiy, A.V.; Jain, P.; Shi, F.; Lushington, G.H.; Santini, C.; Porubsky, P.; Larock, R.C. Solution-Phase Synthesis of a Diverse Library of Benzisoxazoles Utilizing the [3 + 2] Cycloaddition of in Situ-Generated Nitrile Oxides and Arynes. ACS Comb. Sci. 2013, 15(4), 193-201. Online access to the article.

2012

Fenster, E.; Hill, D.; Reiser, O.; Aubé, J. Automated Three-Component Synthesis of a Library of Lactams. Beilstein J. Org. Chem. 2012, 8, 1804-1813. Online access to the article.

Loh, J.K.; Yoon, S.Y.; Samarakoon, T.B.; Rolfe, A.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Hanson, P. R. Exploring Diversity via a Modular Reaction Pairing Strategy. Beilstein J. Org. Chem. 2012, 8, 1293-1302. Online access to the article.

Wrobel, M.; Aubé, J.; König, B. Parallel Solid Phase Synthesis of Diaryltriazoles. Beilstein J. Org. Chem. 2012, 8, 1027-1036. Part of the thematic series "Recent developments in chemical diversity". Online access to the article.

Zang, Q.; Zhou, A.; Javed, S.; Maity, P.K.; Knudtson, C.A.; Bi, D.; Hastings, J.J.; Basha, F.Z.; Hanson, P.R. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-pot Sulfonylation/Thia-Michael Protocol. Heterocycles2012, 86, 1661-1674. Special Issue Honoring Nobel Laureate Professor Ei-ichi Negishi. Online access to the article.

Zang, Q.; Javed, S.; Zhou, A.; Knudtson, C.A.; Bi, D.; Basha, F.Z.; Hanson, P.R. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles 2012 , 86, 1675-1688. Special Issue Honoring Nobel Laureate Professor Ei-ichi Negishi. Online access to the article.

Chattopadhyay, K.; Fenster, E.; Grenning, A.J.; Tunge, J.A. Palladium-catalyzed substitution of (coumarinyl)methyl-acetates with C-, N- and S-nucleophiles. Beilstein J. Org. Chem. 2012, 8, 1200-1207. Online access to the article.

Faisal, S.; Ullah, F.; Maity, P.K.; Rolfe, A.; Samarakoon, T.B.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Basha, F.Z.; Organ, M.G.; Hanson, P.R. Facile (Triazolyl)methylation of MACOS-derived Benzofused Sultams Utilizing ROMP-derived OTP Reagents. ACS Combi. Sci. 2012, 14(4), 268-272. Online access to the article.

Zang, Q.; Javed, S.; Porubsky, P.; Ullah, F.; Neuenswander, B.; Lushington, G.H.; Basha, F.Z.; Organ, M.G.; Hanson, P.R. Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy ACS Combi. Sci. 2012, 14(3), 211-217. Online access to the article.

Rogness, D.C.; Markina, N.A.; Waldo, J.P.; Larock, R.C. Synthesis of Pyrido[1,2-?]indole Malonates and Amines through Aryne Annulation. Comb. Chem. High Throughput Screening 2012, 77, 2743-2755. Online access to the article.

Fang, Y.; Larock, R.C.; Nucleophilic Addition of 2,3-Pyridyne and Synthesis of Benzonaphthyridinones. Tetrahedron2012, 68, 2819-2826. Online access to the article.

Lu, C.; Larock, R. C.; Synthesis of 9-Substituted Xanthenes by the Condensation of Arynes with ortho-Hydroxychalcones. Tetrahedron Lett. 2012, 53, 2202-2205. Online access to the article.

Lu, C.; Larock, R. C.; Synthesis of Benzisoxazolines by the Coupling of Arynes with Nitrones. J. Org. Chem. 2012, 77, 2279-2284. Online access to the article.

Markina, N.A.; Dubrovskiy, A.V.; Larock, R.C.; One-pot Synthesis of 1-Alkyl-1H-indazoles from 1,1-Dialkylhydrazones via Aryne Annulation. Org. Biomol. Chem. 2012, 10, 2409-2412. Online access to the article.

Perchellet, J.-P. H.; Waters, A. M.; Perchellet, E. M.; Thornton, P. D.; Brown, N.; Hill, D.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Chandrasoma, N.; Buszek, K. R.; Antitumor Effects of Synthetic 6,7-Annulated-4-Substituted Indole Compounds in L1210 Leukemic Cells in Vitro. Anticancer Res. 2012 , 32, 4671-4684. Online access to the article.

Brown, N.; Buszek, K. R.; Regioselectivity of Diels-Alder Reactions Between 6,7-Dehydrobenzofuran and 2-Substituted Furans. Tetrahedron Lett. 2012, 53, 4022-4025. Online access to the article.

2011

Goodell, J.R.; Poole, J.L.; Beeler, A.B.; Aubé, J.; Porco, Jr., J.A. Synthesis and Reactivity of Bicyclo[3.2.1]octanoid-Derived Cyclopropanes. J Org Chem 2011, 76, 9792-9800. Online access to the article.

Zhang, J.; Lushington G.H.; Huan J. Characterizing the diversity and biological relevance of the MLPCN assay manifold and screening set. J Chem Inf Model 2011, 51(6), 1205-1215. Online access to the article.

Zhang, J.; Lushington G.H.; Huan J. The BioAssay network and its implications to future therapeutic discovery. BMC Bioinformatics 2011, 12(Suppl 5), S1. Online access to the article.

Maity, P.K.; Kainz, Q.M.; Faisal, S.; Rolfe, A.; Samarakoon, T.B.; Basha, F.Z.; Reiser, O.; Hanson, P. R. Intramolecular Monomer-on-Monomer (MoM) Mitsunobu Cyclization for the Synthesis of Thiadiazepine-dioxides.Chem. Commun. 2011, 47, 12524-12526. Online access to the article.

Dubrovskiy, A.V.; Larock, R.C. Synthesis of o-(Dimethylamino)aryl Ketones and Acridones by the Reaction of 1,1-Dialkylhydrazones and Arynes. Org Lett 2011, 13, 4136-4139. Online access to the article.

Rogness, D.C.; Larock, R.C. Synthesis of N-Arylisatins by the Reaction of Arynes with Methyl 2-Oxo-2-(arylamino)acetates. J Org Chem 2011, 76, 4980-4986. Online access to the article.

Rolfe, A.; Ullah, F.; Samarakoon, T.B.; Kurtz, R.D.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Santini, C.; Organ, M.G.; Hanson, P.R. Synthesis of Amino-Benzothiaoxazepine-1,1-dioxides Utilizing a Microwave-Assisted, SNAr Protocol. ACS Combi. Sci. 2011, 13, 653-658. Online access to the article.

Thornton, P. D.; Brown, N.; Hill, D.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Buszek, K. R. Application of 6,7-Indole Aryne Cycloaddition and Pd(0)-Catalyzed Suzuki-Miyaura and Buchwald-Hartwig Cross-Coupling Reactions for the Preparation of Annulated Indole Libraries. ACS Comb. Sci. 2011, 13, 443-448. Online access to the article.

Kumar, S.; Painter, T. O.; Benoy, K. P.; Neuenswander, B.; Malinakova, H. C. Application of Sequential Cu(I)/Pd(0)-Catalysis to Solution-Phase Parallel Synthesis of Combinatorial Libraries of Dihydroindeno[1,2-c]isoquinolines. ACS Comb. Sci. 2011, 13, 466-477. Online access to the article.

Rolfe, A.; Ullah, F.; Samarakoon , T. B.; Kurtz, R. D.; Porubsky, P.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Organ, M. G.; Hanson, P. R. Microwave-Assisted SNAr diversification of MACOS-derived Amino-Benzothiaoxazepine-1,1-dioxides. ACS J. Comb. Sci. 2011, 13, (online). Online access to the article.

Cho, C.-H.; Jung, D.-I.; Neuenswander, B.; Larock, R.C. Parallel Synthesis of a Desketoraloxifene Analog Library via Iodocyclization/Palladium-Catalyzed Coupling. ACS Comb. Sci. 2011 , 13, 501-510. Online access to the article.

Samarakoon, T.B.; Loh, J.K.; Rolfe, A.; Le, L.S.; Yoon, S.Y.; Lushington, G.H.; Hanson, P.R. A Modular Reaction Pairing Approach to the Diversity-Oriented Synthesis of Fused- and Bridged-Polycyclic Sultams. Org. Lett. 2011, 13(19), 5148-5151. Online access to the article.

Rolfe, A.; Painter, T.O.; Asad, N.; Hur, M.Y.; Jeon, K.O.; Brzozowski, M.; Klimberg, S.V.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Santini, C.; Hanson, P.R. Triazole-Containing Isothiazolidine 1,1-Dioxide Library Synthesis: One- Pot, Multi-Component Protocols for Small Molecular Probe Discovery. ACS Comb. Sci. 2011, 13, 511-517. Online access to the article.

Painter, T.O.; Thornton, P.D.; Orestano, M.; Santini, C.; Organ, M.G.; Aubé, J. In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format. Chem. Eur. J. 2011, 17, 9595-9598. Online access to the article.

Asad, N.; Hanson, P.R.; Long, T.R.; Rayabarapu, D.K.; Rolfe, A. Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol. Chem. Commun. 2011, 47, 9528-9530. Online access to the article.

Coombs, T.C.; Lushington, G.H.; Douglas, J.; Aubé, J. 1,3-Allylic Strain as a Strategic Diversification Element for Constructing Libraries of Substituted 2-Arylpiperidines. Angewandte Chemie, International Edition 2011, 50(12), 2734-2737. Online access to the article.

Ghosh, P.; Aubé, J. Resolution of Carboxylic Acids Using Copper (I)-Promoted Removal of Propargylic Esters Under Neutral Conditions. J Org. Chem. 2011, 76, 4168-4172. Online access to the article.

Huh, C.W.; Schroeder, C.; Singh, G.; Aubé, J. Stereoselectivity in Nucleophilic Additions to 3-Azidoalkanals. J. Org. Chem. 2011 76, 3160-3165. Online access to the article.

Fenster, E.; Fehl, C.; Aubé, J. Use of a Tandem Prins/Friedel-Crafts Reaction in the Construction of the Indeno-Tetrahydropyridine Core of the Haouamine Alkaloids: Formal Synthesis of (-)-Haouamine A." Org. Lett. 2011, 13(10), 2614-2617. Online access to the article.

Long, T. R.; Faisal, S.; Maity, P. K.; Rolfe, A.; Kurtz, R.; Klimberg, S. K.; Najjar, R.; Basha, F.; Hanson, P. R. “Click”-Capture, Ring-Opening Metathesis Polymerization (ROMP), Release: Facile Triazolation Utilizing ROMP-Derived Oligomeric Phosphates. Org. Lett. 2011, 13, 2038-2041. Online access to the article.

Ehlers, I.; Maity, P.; Aube, J.; Konig, B. Modular Synthesis of Triazole-Containing Triaryl Alpha-Helix Mimetics. Eur. J. Org. Chem. 2011, 13, 2474-2490. Online access to the article.

Frankowski, Kevin J.; Setola, Vincent; Evans, Jon M.; Neuenswander Ben; Roth, Bryan L.; Aube, Jeffrey. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class fo sigma ligands. PNAS 2011, 108(17), 6727-6732. Online access to the article.

Maity, Pradip K.; Rolfe, Alan; Samarakoon, Thiwanka B.; Faisal, Saquib; Kurtz, Ryan D.; Long, Toby, R.; Schtz, Alexander; Flynn, Daniel L.; Grass, Robert N.; Stark, Wendelin J.; Reiser, Oliver; and Hanson, Paul R. Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration. Org. Lett. 2011, 13(1), 8-10. Online access to the article.

Rolfe, Alan; Loh, Joanna K.; Maity, Pradip K.; and Hanson, Paul R. High-Load, Hybrid Si-ROMP Reagents. Org. Lett.2011, 13(1), 4-7. Online access to the article.

Cho, C.-H.; Larock, R. C. Highly Substituted Lactone/Ester-Containing Furan Library by the Palladium-Catalyzed Carbonylation of Hydroxyl-Substituted 3-Iodofurans. ACS Comb. Sci. 2011, 13, 272-279. Online access to the article.

Markina, N., Mancuso, R., Neuenswander, B., Lushington, G., Larock, R. Solution-Phase Parallel Synthesis of a Diverse Library of 1,2-Dihydroisoquinolines. ACS Comb. Sci. 2011, 13, 265-271. Online access to the article.

Fenster, E.; Long, T.; Zang, Q.; Hill, D.; Neuenswander, B.; Lushington, G.H.; Zhao, A.; Santini, C.; Hanson, P. Automated Synthesis of a 184-Member Library of Thiadiazepan-1,1-dioxide-4-ones. ACS Comb. Sci.2011, 13, 244-250. Online access to the article.

2010

Achanta, S.; Liautard, V.; Paugh, R.; Organ, M.G. The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products Using Continuous Flow Techniques. Chem. Eur. J. 2010, 16(43), 12797-12800.Online access to the article.

Kivrak, A.; Larock, R. C. Synthesis of Dihydrobenzisoxazoles by the [3+2] Cycloaddition of Arynes and Oxaziridines.J. Org. Chem. 2010, 75, 7381-7387. Online access to the article.

Rolfe, A.; Samarakoon, T. B.; Klimberg, S. V.; Brzozowski, M.; Neuenswander, B.; Lushington, G. H.; Hanson, P. R. SNAr-Based, Facile Synthesis of a Library of Benzothiaoxazepine-1,1?-dioxides. J. Comb. Chem. 2010, 12(6), 850-854. Online access to the article.

Ullah, F.; Samarakoon, T.; Rolfe, A.; Kurtz, R. D.; Hanson, P. R.; Organ, M. G. Scaling Out by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): Multi-Gram Synthesis of Bromo- and Fluoro-benzofused Sultams Benzthiaoxazepine-1,1-dioxides. Chem. Eur. J. 2010, 16(36), 10959-10962. Online access to the article.

Dubrovskiy, A. V.; Larock, R. C. Intermolecular C-O addition of carboxylic acids to arynes. Org. Lett. 2010, 12(14), 3117-3119. Online access to the article.

Torregrosa, R. R. P.; Ariyarathna, Y.; Chattopadhyay, K.; Tunge, J. A. Decarboxylative Benzylations of Alkynes and Ketones. J. Am. Chem. Soc. 2010, 132(27), 9280-9282. Online access to the article.

Chattopadhyay, K.; Jana, R.; Day, V. W.; Douglas, J. T.; Tunge, Jon A. Mechanistic Origin of the Stereodivergence in Decarboxylative Allylation. Org. Lett. 2010, 12(13), 3042-3045. Online access to the article.

Smalter, A.; Huan,J.; Jia, Y.; Lushington, G.H. GPD: A Graph Pattern Diffusion Kernel for Accurate Graph Classification with Applications in Cheminformatics. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2010, 7, 197-207. Online access to the article.

Cho, C.-H.; Larock, R. C. A Convenient Synthetic Route to Furan Esters and Lactones by Palladium-Catalyzed Carboalkoxylation or Cyclocarbonylation of Hydroxyl-Substituted 3-Iodofurans. Tet. Lett. 2010, 51, 3417-3421. Online access to the article.

Cho, C.-H.; Jung, D.-I.; Larock, R. C. A New Approach to Desketoraloxifene Analogs from Oxygen-bearing 3-Iodobenzo[b]thiophenes Prepared via Iodocyclization. Tet. Lett. 2010, 51, 6485-6488. Online access to the article.

Long, T. R.; Maity, P. K.; Samarakoon, T. B. and Hanson, P. R. ROMP-Derived Oligomeric Phosphates for Application in Facile Benzylation. Org. Lett. 2010, 12(13), 2904-2907. Online access to the article.

Frankowski, K. J.; Ghosh, P.; Setola, V.; Tran, T. B.; Roth, B. L. and Aubé, J. N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic Kappa-Opioid Receptor Ligands. ACS Med. Chem. Lett. 2010, 1(5), 189-193.Online access to the article.

Wu, C.; Fang, Y.; Larock, R. C.; Shi, F. Synthesis of 2H-Indazoles by the [3+2] Cycloaddition of Arynes and Sydnones. Org. Lett. 2010, 12, 2234-2237. Online access to the article.

Samarakoon, T. B.; Hur, M. Y.; Kurtz, R. D.; Hanson, P. R. A Formal [4+4] Complementary Ambiphile Pairing (CAP) Reaction: A New Cyclization Pathway for ortho-Quinone Methides. Org. Lett. 2010, 2182-2185. Online access to the article.

Treece, J. L.; Goodell, J. R.; Vander Velde, D.; Porco, Jr., J. A.; and Aubé, J. Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers. J. Org. Chem. 2010, 75, 2028-2038. Online access to the article.

Mehta, S.; Larock, R. C. Iodine/Palladium Approaches to the Synthesis of Polyheterocyclic Compounds. J. Org. Chem. 2010, 75, 1652-1658. Online access to the article.

Dubrovskiy, A. V.; Larock, R. C. Synthesis of Benzisoxazoles by the [3+2] Cycloaddition of in situ Generated Nitrile Oxides and Arynes. Org. Lett. 2010, 12, 1180-1183. Online access to the article.

Rolfe, A.; Lushington, G. H.; Hanson, P. R. Reagent based DOS: A Click, Click, Cyclize strategy to probe chemical space. Org. Biomol. Chem. 2010, 8, 2198-2203. Online access to the article.

Rogness, D. C.; Larock, R. C. Synthesis of Acridines by the [4+2] Annulation of Arynes and 2-Aminoaryl Ketones. J. Org. Chem. 2010, 75, 2289-2295. Online access to the article.

Rolfe, A.; Samarakoon, T. B.; Hanson, P. R. Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy. Org. Lett. 2010, 12, 1216-1219. Online access to the article.

Garr, A. N.; Luo, D.; Brown, N.; Cramer, C. J.; Buszek, K. R.; VanderVelde, D. Experimental and Theoretical Investigations into the Unusual Regioselectivity of 4,5-, 5,6-, and 6,7-Indole Aryne Cycloadditions. Org. Lett. 2010, 12(1), 96-99. Online access to the article.

Cho, C.-H., Neuenswander, B., Larock, R.C. Diverse Methyl Sulfone-Containing Benzo[b]thiophene Library via Iodocyclization and Palladium-Catalyzed Coupling. J. Comb. Chem. 2010, 12(2), 278-285. Online access to the article.

2009

Wang, C.; Pahadi, N.; Tunge, J. A. Decarboxylative cyclizations and cycloadditions of palladium-polarized aza-ortho-xylylenes. Tetrahedron 2009, 65, 5102-5109. Online access to the article.

Xiaohong W., Smalter, A., Huan, J., Lushington, G. H. G-Hash: Towards Fast Kernel-based Similarity Search in Large Graph Databases. Proceedings of the 12th International Conference on Extending Database Technology (EDBT'09)2009, 472-480. Online access to the article.

Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; and Tunge, J. A. Formation of N-alkylpyrroles via intermolecular redox amination. J. Am. Chem. Soc. 2009, 131, 16626-16627. Online access to the article.

Jeon, K.; Rayabarapu, D.; Rolfe, A.; Volp, K.; Omar, I.; Hanson, P. R. Metathesis Cascade Strategies (ROM-RCM-CM): A DOS Approach to Skeletally Diverse Sultams. Tetrahedron 2009, 65, 4992-5000. Online access to the article.

Smalter, A.; Huan, J.; Lushington, G. Graph Wavelet Alignment Kernels for Drug Virtual Screening. J. Bioinform. Comput. Biol. 2009, 7, 473-497. Online access to the article.

Brown, N.; Luo, D.; Decapo, J. A.; Buszek, K. R. New Synthesis of (±)-Cis-Trikentrin A via Tandem Indole Aryne Cycloaddition/Negishi Reaction. Applications to Library Development. Tetrahedron Lett. 2009, 50(51), 7113-7115.Online access to the article.

Rolfe, A.; Hanson, P. R. Microwave-assisted Sequential One-pot Protocol to Benzothiadiazin-3-one-1,1-dioxides via a Copper-catalyzed N-Arylation Strategy. Tetrahedron Lett. 2009, 50(50), 6935-3937. Online access to the article.

Worlikar, S. A.; Larock, R. C. Synthesis of 9-Fluorenylidenes and 9,10-Phenanthrenes through Palladium-catalyzed Aryne Annulation by o-Halostyrenes and o-Halo Allylic Benzenes. J. Org. Chem. 2009, 74, 9132-9139. Online access to the article.

Perchellet, J-P.H.; Perchellet, E.M.; Crow, K.R.; Buszek, K.R.; Brown, N.; Ellappan, S.; Gao, G.; Luo, D.; Minatoya, M.; Lushington, G.H. Novel Synthetic Inhibitors of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Activity that Inhibit Tumor Cell Proliferation and are Structurally Unrelated to Existing Statins. Int. J. Mol. Med. 2009, 24(5), 633-643. (Cover Article) Online access to the article.

Ward, T.R.; Turunen, B.J.; Haack, T.; Neuenswander, B.; Shadrick, W.; Georg, G.I. Synthesis of a quinolone library from ynones. Tetrahedron Lett. 2009, 50(47), 6494-6497. Online access to the article.

Chen, Y.; Cho, C.-H.; Shi, F.; Larock, R. C. Synthesis of 3-Sulfenyl- and 3-Selenylindoles by the Pd/Cu-Catalyzed Coupling of N,N-Dialkyl-2-iodoanilines and Terminal Alkynes, Followed by n-Bu4NI-Induced Electrophilic Cyclization. J. Org. Chem. 2009, 74, 6802-6811. Online access to the article.

Jana, R.; Trivedi, R.; Tunge, J. A. Mild Decarboxylative Allylation of Coumarins. Org. Lett. 2009, 11(15), 3434-3436.Online access to the article.

Duan, S.; Jana, R.; Tunge, J. A. Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters.J. Org. Chem. 2009, 74(12), 4612-4614. Online access to the article.

Chen, Y.; Markina, N. A.; Larock, R. C. An Efficient, Microwave-Assisted, One-Pot Synthesis of Indoles Under Sonogashira Conditions. Tetrahedron 2009, 65, 8908-8915. Online access to the article.

Shi, F; Mancuso, R.; Larock, R. C. 1,3-Dipolar Cycloaddition of Arynes with Azomethine Imines: Synthesis of 1,2-Dihydropyrazolo[1,2-a]indazol-3(9H)-ones. Tetrahedron Lett. 2009, 50, 4067-4070. Online access to the article.

Rogness, D.; Larock, R. C. Rapid Synthesis of the Indole-Indolone Scaffold via [3+2] Annulation of Arynes by Methyl Indole-2-carboxylates. Tetrahedron Lett. 2009 , 50, 4003-4008. Online access to the article.

Worlikar, S. A.; Larock, R. C. Palladium-Catalyzed Synthesis of 9-Fluorenylidenes through Aryne Annulation. Org. Lett. 2009, 11(11), 2413-2416. Online access to the article.

Cho, C. H.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Solution-Phase Parallel Synthesis of a Multi-substituted Benzo[b]thiophene Library. J. Comb. Chem. 2009, 11, 900-906. Online access to the article.

Worlikar, S. A.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Highly Substituted Indole Library Synthesis by Palladium-Catalyzed Coupling Reactions in Solution and on a Solid Support. J. Comb. Chem. 2009, 11, 875-879.Online access to the article.

Hershberger, J. C.; Day V. W.; Malinakova, H. C. Diastereoinduction in the Synthesis of Pallada(II)pyrrolidinones: Palladacycles with Two Pd-bonded Stereogenic Carbons. Organometallics 2009, 28(3), 810–818. Online access to the article.

Rolfe, A.; Young, K.; Volp, K.; Schoenen, F. J.; Neuenswander, B.; Lushington, G. H.; Hanson, P. R. One-Pot, Three-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1, 2-benzisothiazoline-3-acetic Acids. J. Comb. Chem. 2009, 11(4), 732-738. Online access to the article.

Rayabarapu, D. K.; Zhou, A.; Jeon, K. O.; Samarakoon, T.; Rolfe, A.; Siddiqui, H.; Hanson, P. R. a-Haloarylsulfonamides: Multiple Cyclization Pathways to Skeletally Diverse Benzofused Sultams. Tetrahedron 2009, 65(16), 3180-3188. Online access to the article.

Thiruvellore, T. J.; Lei, Z.; Johnson, T. S.; Malinakova, H. C. Sequential Cu(I)/Pd(0)-Catalyzed Multicomponent Coupling and Annulation Protocol for the Synthesis of Indenoisoquinolines. Org. Lett. 2009, 11(4), 815-818. Online access to the article.

Zhou, A.; Rayabarapu, D.; Hanson, P. R. Click, Click, Cyclize: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchpins. Org. Lett. 2009, 11(3), 531-534. Online access to the article.

Verma, A. K.; Kesharwani, T.; Singh, J.; Tandon, V.; Larock, R. C. A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines. Angew. Chem, Int. Ed. 2009, 48(6), 1138-1143. Online access to the article.

Mehta, S.; Waldo, J. P.; Larock, R. C. Competition Studies in Alkyne Electrophilic Cyclization Reactions. J. Org. Chem. 2009, 74(3), 1141-1147. Online access to the article.

Buszek, K. R.; Brown, N.; Luo, D. Concise Total Synthesis of (±)-cis-Trikentrin A and (±)-Herbindole A via Intermolecular Indole Aryne Cycloaddition. Org. Lett. 2009, 11(1), 201-204. Online access to the article.

Chen, Y.; Cho, C. H.; Larock, R. C. A Novel Synthetic Route to 3-Sulfenyl- and 3-Selenylindoles by n-Bu4NI-Induced Electrophilic Cyclization. Org. Lett. 2009, 11(1), 173-176. Online access to the article.

Brown, N.; Luo, D.; VanderVelde, D.; Yang, S.; Brassfield, A.; Buszek, K. R. Regioselective Diels-Alder Cycloadditions and Other Reactions of 4,5-, 5,6-, and 6,7-Indole Arynes. Tetrahedron Lett. 2009, 50(1), 63-65. (Cover Article on the 50th Anniversary Cover) Online access to the article.

Roy, S., Roy, S., Neuenswander, B., Hill, D., Larock, R.C. Solution-Phase Synthesis of a Diverse Isocoumarin Library. J. Comb. Chem. 2009 11(6), 1128-1135. Online access to the article.

Roy, S., Roy, S., Neuenswander, B., Hill, D., Larock, R.C. Palladium- and Copper-Catalyzed Solution Phase Synthesis of a Diverse Library of Isoquinolines. J. Comb. Chem. 2009 11(6), 1061-1065. Online access to the article.

2008

Cho, C. H.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Parallel Synthesis of a Multi-Substituted Benzo[b]furan Library. J. Comb. Chem. 2008, 10(6), 941-947. Online access to the article.

Frankowski, K. J.; Neuenswander, B.; Aubé, J. Explorations of Stemona Alkaloid-Inspired Analogues: Skeletal Modification and Functional Group Diversification. J. Comb. Chem. 2008, 10(5), 721–725. Online access to the article.

Waldo, J. P.; Mehta, S.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Solution Phase Synthesis of a Diverse Library of Highly Substituted Isoxazoles. J. Comb. Chem. 2008, 10(5), 658-663. Online access to the article.

Rolfe, A.; Probst, D. A.; Volp, K. A.; Omar, I.; Flynn, D. L.; Hanson, P. R. High-load, Oligomeric Dichlorotriazine: A Versatile ROMP-Derived Reagent and Scavenger. J. Org. Chem. 2008, 73(22), 8785-8790. Online access to the article.

Li, K.; Tunge, J. A. Reduction of Pyrrolyl- and Indolylamides with BH3•THF: Cyclodeoxygenation versus Deoxygenation. J. Org. Chem. 2008, 73(21), 8651-8653. Online access to the article.

Worlikar, S. A.; Larock, R. C. Palladium-Catalyzed One Step Synthesis of Isoindole-1,3-diones by Carbonylative Cyclization of o-Halobenzoates and Primary Amines. J. Org. Chem. 2008, 73(18), 7175-7180. Online access to the article.

Shore, G.; Organ, M. G. Gold-film-catalysed hydrosilylation of alkynes by microwave-assisted, continuous flow organic synthesis (MACOS). Chem. Eur. J. 2008, 14(31), 9641-9646. Online access to the article.

Rolfe, A.; Young, K.; Hanson, P. R. Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid. Eur. J. Org. Chem. 2008, 31, 5254 - 5262. Online access to the article.

Gao, G.; Brown, N.; Minatoya, M.; Buszek, K.R. N-Vinylpyridinium tetrafluoroborate salts as reagents for the stereoselective and regioselective synthesis of symmetrical (2E,4E)-1,6-dioxo-2,4-dienes. Tetrahedron Lett. 2008, 49(46), 6491-6494. Online access to the article.

Shore, G.; Organ, M. G. Diels-Alder Cycloadditions by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): The Role of Metal Films in the Flow Tube. Chem. Commun. 2008, 838-840. Online access to the article.

Brown, N.; Xie, B.; Markina, N.; VanderVelde, D.; Perchellet, J.-P. H.; Perchellet, E. M.; Crow, K. R.; Buszek, K. R. Synthesis of a Natural Product-inspired Eight-membered Ring Lactam Library via Ring-closing Metathesis. Bioorg. Med. Chem. Lett. 2008, 18(17), 4876–4879. Online access to the article.

Waldo, J. P.; Zhang, X; Shi, F.; Larock, R. C. Efficient Synthesis of Fluoren-9-ones by the Palladium-Catalyzed Annulation of Arynes by 2-Haloarenecarboxaldehydes. J. Org. Chem. 2008, 73(17), 6679-6685. Online access to the article.

Waldo, J. P.; Mehta, S.; Larock, R. C. Room Temperature ICl-Induced Dehydration/Iodination of 1-Acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles. A Selective Route to Substituted 1-Acyl-4-iodo-1H-pyrazoles. J. Org. Chem. 2008, 73(17), 6666-6670. Online access to the article.

Shore, G.; Morin, S.; Mallik, D.; Organ, M. G. Pd PEPPSI-IPr-Mediated Reactions in Metal-Coated Capillaries Under Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): The Synthesis of Indoles by Sequential Aryl Amination/Heck Coupling. Chem. Eur. J. 2008, 14(4), 1351-1356. Online access to the article.

Aubé, J.; Frankowski, K.; Neuenswander, B. Explorations of Stemona Alkaloid-Inspired Analogues: Skeletal Modification and Functional Group Diversification. J. Comb. Chem. 2008, 10(5), 721–725. Online access to the article.

Brown, N.; Gao, G.; Minatoya, M.; Xie, B.; VanderVelde, D.; Lushington, G. H.; Perchellet, J.-P. H.; Perchellet, E. M.; Crow, K. R.; Buszek, K. R. Design and Synthesis of Medium-Ring Lactam Libraries Inspired by Octalactin A. A Convergent-Divergent Approach. J. Comb. Chem. 2008, 10(5),628–631. Online access to the article.

Poon, K. W. C.; Datta, A. A Rapid Synthetic Route to Conformationally Restricted [5,5]-Bicyclic Nucleoside-Amino Acid Conjugates. Nucleosides, Nucleotides Nucleic Acids 2008, 27(8), 914–930. Online access to the article.

Zhou, A.; Hanson, P. R. Synthesis of Sultam Scaffolds via Intramolecular Oxa-Michael and Diastereoselective Baylis-Hillman Reactions. Org. Lett2008, 10(14), 2951–2954. Online access to the article.

Shi, F.; Waldo, J. P.; Chen, Y.; Larock, R. C. Benzyne Click Chemistry: Synthesis of Benzotriazoles from Benzynes and Azides. Org. Lett2008, 10(12), 2409–2412. Online access to the article.

Stoianova, D. S.; Yao, L.; Rolfe, A.; Samarakoon, T.; Hanson, P. R. High-load, oligomeric monoamine hydrochloride: facile generation via ROM polymerization and application as an electrophile scavenger. Tetrahedron Lett. 2008, 49(29-30), 4553-4555. Online access to the article.

Jiménez-Hopkins, M.; Hanson, P. R. An RCM Strategy to Stereodiverse δ-Sultam Scaffolds. Org. Lett. 2008, 10(11), 2223–2226. Online access to the article.

Frankowski, K. J.; Golden, J. E.; Zeng, Y.; Lei, Y.; Aubé, J. Syntheses of the Stemona Alkaloids (±)-Stenine, (±)-Neostenine, and (±)-13-Epineostenine Using a Stereodivergent Diels-Alder/Azido-Schmidt Reaction. J. Am. Chem. Soc. 2008, 130(18), 6018-6024. Online access to the article.

Stensrud, K. F., Heger, D., Šebej, P., Wirz, J., Givens, R. S. Fluorinated photoremovable protecting groups: The influence of fluoro substituents on the photo-Favorskii rearrangement. Photochem. Photobiol. Sci. 2008, 7(5), 614-624. Online access to the article.

Nöth, J.; Frankowski, K. J.; Neuenswander, B.; Aubé, J.; Reiser, O. Efficient Synthesis of γ-Lactams by a Tandem Reductive Amination/Lactamization Sequence. J. Comb. Chem. 2008, 10(3), 456–459. Online access to the article.

Poon, K. W. C.; Liang, N.; Datta, A. De Novo Synthetic Route to a Combinatorial Library of Peptidyl Nucleosides.Nucleosides, Nucleotides Nucleic Acids 2008, 27(4), 389-407. Online access to the article.

Just, Z. W.; Larock, R. C. Synthesis of 2(3H)-Furanones via Electrophilic Cyclization. J. Org. Chem. 2008, 73(7), 2662-2667. Online access to the article.

Ge, H.; Niphakis, M. J.; Georg, G. I. Palladium(II)-Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates. J. Am. Chem. Soc. 2008, 130(12), 3708-3709. Online access to the article.

Theertham, B.; Wang, J. L.; Fang, J.; Lushington, G. H. Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics. Curr. Comput.-Aided Drug Des. 2008, 4(1), 23-34. Online access to the article.

Givens, R. S.; Heger, D.; Hellrung, B.; Kamdzhilov, Y.; Mac, M.; Conrad, P. G., II; Cope, E.; Lee, J. I.; Mata-Segreda, J. F.; Schowen, R. L.; Wirz, J. The Photo-Favorskii Reaction of p-Hydroxyphenacyl Compounds is Initiated by Water-Assisted, Adiabatic Extrusion of a Triplet Biradical. J. Am. Chem. Soc. 2008, 130(11), 3307-3309. Online access to the article.

Zhang, L.; Lushington, G. H.; Neuenswander, B.; Hershberger, J. C.; Malinakova, H. C. Solution-Phase Parallel Synthesis of Hexahydro-1H-isoindolone Libraries via Tactical Combination of Cu-Catalyzed Three-Component Coupling and Diels-Alder Reactions. J. Comb. Chem. 2008, 10(2), 285-302. Online access to the article.

Fenster, E.; Rayabarapu, D. K.; Zhang, M.; Mukherjee, M.; Hill, D.; Neuenswander, B.; Schoenen, F.; Hanson, P. R.; Aubé, J. Three-Component Synthesis of 1,4-Diazepin-5-ones and the Construction of γ-Turn-like Peptidomimetic Libraries. J. Comb. Chem. 2008, 10(2), 230-234. Online access to the article.

Vedantham, P., Zhang, M., Gor, P. J., Huang, M., Georg, G. I., Lushington, G. H., Mitscher, L. A., Ye, Q.-Z., Hanson, P. R. Studies Towards Synthesis of Methionine Aminopeptidase Inhibitors: Diversification Utilizing a ROMP-Derived Coupling Reagent. J. Comb. Chem. 2008, 10(2), 195-203. Online access to the article.

Vedantham, P.; Guerra, J. M.; Schoenen, F.; Huang, M.; Gor, P. J.; Georg, G. I.; Wang, J. L.; Neuenswander, B.; Lushington, G. H.; Mitscher, L. A.; Ye, Q.-Z.; Hanson, P. R. Ionic Immobilization, Diversification and Release: Application to the Generation of a Library of Methionine Aminopeptidase Inhibitors. J. Comb. Chem. 2008, 10(2), 185-194. Online access to the article.

Smalter, A., Huan, J., Lushington, G. Structure-based Pattern Mining For Chemical Compound Classification. Series on Advances in Bioinformatics and Computational Biology: Proceedings of the 6th Asia Pacific Bioinformatics Conference (APBC) 2008, 6, 39-48.

Li, K.; Tunge, J. A. Chemical Libraries via Sequential C-H Functionalization of Phenols. J. Comb. Chem. 2008, 10(2), 170-174. Online access to the article.

Poon, K. W. C.; Lovell, K. M.; Dresner, K. N.; Datta, A. Trimethylsilyl trifluoromethanesulfonate (TMSOTf) assisted facile deprotection of N,O-acetonides. J. Org. Chem. 2008, 73(2), 752-755. Online access to the article.

Liu, Z.; Shi, F.; Martinez, P. D. G.; Raminelli, C.; Larock, R. C. Synthesis of Indazoles by the [3+2] Cycloaddition of Diazo Compounds with Arynes and Subsequent Acyl Migration. J. Org. Chem. 2008, 73(1), 219-226. Online access to the article.

Fenster, E., Smith, B. T., Gracias, V., Milligan, G. L., and Aubé, J. Nucleophilic Addition to Iminium Ethers in the Preparation of Functionalized N-Alkyl Heterocycles. J. Org. Chem. 2008, 73(1), 201-205. Online access to the article.

2007

Wang, Xin; Turunen, B. J.; Leighty, M. W.; Georg, G. I. Microwave-assisted Suzuki–Miyaura couplings on α-iodoenaminones. Tetrahedron Lett. 2007, 48(50), 8811-8814. Online access to the article.

Waldo, J. P.; Larock, R. C. The Synthesis of Highly Substituted Isoxazoles by Electrophilic Cyclization: An Efficient Synthesis of Valdecoxib. J. Org. Chem. 2007, 72(25), 9643-9647. Online access to the article.

Frankowski, K. J.; Hirt, E. E.; Zeng, Y.; Neuenswander, B.; Fowler, D.; Schoenen, F.; Aubé, J. Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxamide Libraries Using a Tandem Diels–Alder/Acylation Sequence. J. Comb. Chem. 2007, 9(6), 1188–1192. Online access to the article.

Buszek, K. R.; Luo, D.; Kondrashov, M.; Brown, N.; VanderVelde, D. Indole-Derived Arynes and Their Diels-Alder Reactivity with Furans. Org. Lett. 2007, 9(21), 4135 -4137. Online access to the article.

Chaudhry, P.; Schoenen, F.; Neuenswander, B.; Lushington, G. H.; Aubé, J. One-Step Synthesis of Oxazoline and Dihydrooxazine Libraries. J. Comb. Chem. 2007, 9(3), 473 - 476. Online access to the article.

Huang, Y–T.; Blagg, B. S. J. A Library of Noviosylated Coumarin Analogues. J. Org. Chem. 2007, 72(10), 3609 - 3613.Online access to the article.

Zhang, M.; Flynn, D. L.; Hanson, P. R. Oligomeric Benzylsulfonium Salts: Facile Benzylation via High-Load ROMP Reagents. J. Org. Chem. 2007, 72(9), 3194-3198. Online access to the article.

Buszek, K.R.; Brown, N. Improved Method for the Diimide Reduction of Multiple Bonds on Solid-Supported Substrates. J. Org. Chem. 2007, 72(8), 3125 - 3128. Online access to the article.

Buszek, K. R.; Brown, N. N-Vinylpyridinium and -ammonium Tetrafluoroborate Salts: New Electrophilic Coupling Partners for Pd(0)-Catalyzed Suzuki Cross-Coupling Reactions. Org. Lett. 2007, 9(4), 707 - 710. Online access to the article.

Liu, Z.; Larock, R. C. Palladium-Catalyzed, Sequential, Three-Component Cross-Coupling of Aryl Halides, Alkynes, and Arynes. Angew. Chem., Int. Ed. 2007, 46(14), 2535 - 2538. Online access to the article.

Zhang, L.; Malinakova, H. C. Copper-Catalyzed Multicomponent Cascade Process for the Synthesis of Hexahydro-1H-isoindolones. J. Org. Chem. 2007, 72(4), 1484 - 1487. Online access to the article.

Worlikar, S. A.; Kesharwani, T.; Yao, T.; Larock, R. C. Synthesis of 3,4-Disubstituted 2H-Benzopyrans through C-C Bond Formation via Electrophilic Cyclization. J. Org. Chem. 2007, 72(4), 1347 - 1353. Online access to the article.

Zhao, J.; Larock, R. C. Synthesis of Xanthones, Thioxanthones, and Acridones by the Coupling of Arynes and Substituted Benzoates. J. Org. Chem. 2007, 72(2), 583 - 588. Online access to the article.

Liu, Z.; Larock, R. C. Synthesis of carbazoles and dibenzofurans via cross-coupling of o-iodoanilines and o-iodophenols with silylaryl triflates and subsequent Pd-catalyzed cyclization. Tetrahedron 2007, 63(2), 347-355. Online access to the article.

Manyem, S.; Sibi, M. P.; Lushington, G. H.; Neuenswander, B.; Schoenen, F.; Aubé, J. Solution-Phase Parallel Synthesis of a Library of Δ2-Pyrazolines. J. Comb. Chem. 2007, 9(1), 20-28. Online access to the article.

Liu, Z.; Larock, R. C. Highly Efficient Route to Fused Polycyclic Aromatics via Palladium-Catalyzed Aryne Annulation by Aryl Halides. J. Org. Chem. 2007, 72(1), 223 - 232. Online access to the article.

2006

Laursen, J. B.; Nielsen, J.; Haack, T.; Pusuluri, S.; David, S.; Balakrishna, R.; Zeng, Y.; Ma, Z.; Doyle, T. B.; Mitscher, L. A. Further Exploration of Antimicrobial Ketodihydronicotinic Acid Derivatives by Multiple Parallel Syntheses. Comb. Chem. High Throughput Screening 2006, 9(9), 663-681. Online access to the article.

Ward, T. R.; Georg, G. I. N,O-Dimethylhydroxylamine. Fuchs, P. L. Ed.; In Electronic Encyclopedia of Reagents in Organic Synthesis (e-EROS). Wiley, Chichester 2006.

Chaudhury, S.; Welch, T. R.; Blagg, B. S. J. Hsp90 as a Target for Drug Development. ChemMedChem 2006, 1(12), 1331-1340. Online access to the article.

Li, K.; Vanka, K.; Thompson, W. H.; Tunge, J. A. Stereochemical Control in the Reduction of 2-Chromanols. Org. Lett.2006, 8(21), 4711-4714. Online access to the article.

Herpel, R. H.; Vedantham, P.; Flynn, D. L.; Hanson, P. R. High-Load, Oligomeric Phosphonyl Dichloride: Facile Generation via ROM Polymerization and Application to Scavenging Amines. Tetrahedron Lett. 2006, 47(36), 6429-6432. Online access to the article.

Turunen, B. J.; Georg, G. I. Amino Acid-Derived Enaminones: A Study in Ring Formation Providing Valuable Asymmetric Synthons. J. Am. Chem. Soc.2006, 128(27), 8702 - 8703. Online access to the article.

Yue, D.; Cá, N. D.; Larock, R. C. Syntheses of Isochromenes and Naphthalenes by Electrophilic Cyclization of Acetylenic Arenecarboxaldehydes. J. Org. Chem. 2006, 71(9), 3381-3388. Online access to the article.

Liu, Z.; Larock, R. C. Facile N-Arylation of Amines and Sulfonamides and O-Arylation of Phenols and Arenecarboxylic Acids. J. Org. Chem. 2006, 71(8), 3198-3209. Online access to the article.

Peng, W.; Blagg, B. S. J. A Versatile Approach toward the Ansamycin Antibiotics. Org. Lett. 2006, 8(5), 975-978. Online access to the article.

Schoenen, F. J.; Aubé, J. Arthur Suite V. 3.0 Symyx Technologies, Inc. (Computer Software Review) J. Am. Chem. Soc.2006, 128(2), 664-665. Online access to the article.

Kesharwani, T.; Worlikar, S. A.; Larock, R. C. Synthesis of 2,3-Disubstituted Benzo[b]selenophenes via Electrophilic Cyclization. J. Org. Chem. 2006, 71(6), 2307-2312. Online access to the article.

Zhou, C.; Dubrovsky, A. V.; Larock, R. C. Diversity-Oriented Synthesis of 3-Iodochromones and Heteroatom Analogues via ICl-Induced Cyclization. J. Org. Chem. 2006, 71(4), 1626-1632. Online access to the article.

Hershberger, J. C.; Zhang, L.; Lu, G.; Malinakova, H. C. Polymer-Supported Palladacycles: Efficient Reagents for Synthesis of Benzopyrans with Palladium Recovery. Relationship among Resin Loading, Pd:P Ratio, and Reactivity of Immobilized Palladacycles. J. Org. Chem. 2006, 71(1), 231-235. Online access to the article.

Yue, D.; Yao, T.; Larock, R. C. Synthesis of 3-Iodoindoles by the Pd/Cu-Catalyzed Coupling of N,N-Dialkyl-2-iodoanilines and Terminal Acetylenes, Followed by Electrophilic Cyclization. J. Org. Chem. 2006, 71(1), 62-69. Online access to the article.

2005

Harned, A. M.; Sherrill, W. M.; Flynn, D. L.; Hanson, P. R. High-load, soluble oligomeric benzenesulfonyl azide: application to facile diazo-transfer reactions. Tetrahedron 2005, 61(51), 12093–12099. Online access to the article.

Waldo, J. P.; Larock, R. C. Synthesis of Isoxazoles via Electrophilic Cyclization. Org. Lett. 2005, 7(23), 5203-5205.Online access to the article.

Yao, T.; Yue, D.; Larock, R. C. An Efficient Synthesis of Coumestrol and Coumestans by Iodocyclization and Pd-Catalyzed Intramolecular Lactonization. J. Org. Chem. 2005, 70(24), 9985-9989. Online access to the article.

Zhao, J.; Larock, R. C. One-Pot Synthesis of Xanthones and Thioxanthones by the Tandem Coupling-Cyclization of Arynes and Salicylates. Org. Lett. 2005, 7(19), 4273-4275. Online access to the article.

Li, K.; Zeng, Y.; Neuenswander, B.; Tunge, J. A. Sequential Pd(II)-Pd(0) Catalysis for the Rapid Synthesis of Coumarins. J. Org. Chem. 2005, 70(16), 6515-6518. Online access to the article.

Dougherty, J. M.; Jiménez, M.; Hanson, P. R. Synthesis of cyclic sulfamoyl carbamates and ureas via ring-closing metathesis. Tetrahedron 2005, 61(26), 6218–6230. Online access to the article.

Zeng, Y.; Qingshan, L., Hanzlik, R. P., Aubé, J. Synthesis of a Small Library of Diketopiperazines as Potential Inhibitors of Calpain. Bioorg. Med. Chem. Lett. 200515, 3034–3038. Online access to the article.

Harned, A. M.; Zhang, M.; Vedantham, P.; Mukherjee, S.; Herpel, R. H.; Flynn, D. L.; Hanson, P. R. ROM Polymerization in Facilitated Synthesis. Aldrichimica ACTA2005, 38, 3-16.

Yao, T.; Yue, D.; Larock, R. C. Solid-Phase Synthesis of 1,2,3-Trisubstituted Indoles and 2,3-Disubstituted Benzofurans via Iodocyclization. J. Comb. Chem. 2005, 7(6), 809-812. Online access to the article.

Givens, R. S.; Lee, J.-I.; Kotala, M. Mechanistic Overview of Phototriggers and Cage Release (Chp. 2) in Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules; J. Wiley, and Sons, 2005; pp 95-129.

Givens, R. S.; Yousef, A. p-Hydroxyphenacyl: A Photoremovable Protecting Group for Caging Bioactive Substrates (Chp. Ic) in Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules; J. Wiley, and Sons,2005; pp 55-75.

Li, K.; Foresee, L. N.; Tunge, J. A. Trifluoroacetic Acid-Mediated Hydroarylation: Synthesis of Dihydrocoumarins and Dihydroquinolones. J. Org. Chem2005, 70(7), 2881-2883. Online access to the article.

Ramanathan, S. K.; Keeler, J.; Lee, H-L.; Reddy, D. S.; Lushington, G.; Aubé, J. Modular Synthesis of Cyclic Peptidomimetics Inspired by γ-Turns. Org. Lett. 2005, 7(6), 1059-1062. Online access to the article.

Mitscher, L. A. Bacterial Topoisomerase Inhibitors: Quinolone and Pyridine Antibacterial Agents. Chem.Rev2005,105(2), 559-592. Online access to the article.

Harned, A. M.; Song He, H.; Toy, P. H.; Flynn, D. L.; Hanson, P. R. Multipolymer Solution-Phase Reactions: Application to the Mitsunobu Reaction. J. Am. Chem. Soc. 2005, 127(1), 52-53. Online access to the article.

2004

Zhang, M.; Moore, J. D.; Flynn, D. L.; Hanson, P. R. Development of High-Load, Soluble Oligomeric Sulfonate Esters via ROM Polymerization: Application to the Benzylation of Amines. Org. Lett. 2004, 6(16), 2657-2660. Online access to the article.

Zhang, M., Vedantham, P.; Flynn, D. L., Hanson, P. R. High-Load, Soluble Oligomeric Carbodiimide: Synthesis and Application in Coupling Reactions. J. Org. Chem. 2004, 69(24), 8340-8344. Online access to the article.

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