NIH-National Institute of General Medical Sciences

2012

Fenster, E.; Hill, D.; Reiser, O.; Aubé, J. Automated Three-Component Synthesis of a Library of Lactams. Beilstein J. Org. Chem. 2012, 8, 1804-1813. Online access to the article.

Loh, J.K.; Yoon, S.Y.; Samarakoon, T.B.; Rolfe, A.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Hanson, P. R. Exploring Diversity via a Modular Reaction Pairing Strategy. Beilstein J. Org. Chem. 2012, 8, 1293-1302. Online access to the article.

Wrobel, M.; Aubé, J.; König, B. Parallel Solid Phase Synthesis of Diaryltriazoles. Beilstein J. Org. Chem. 2012, 8, 1027-1036. Part of the thematic series "Recent developments in chemical diversity". Online access to the article.

Zang, Q.; Zhou, A.; Javed, S.; Maity, P.K.; Knudtson, C.A.; Bi, D.; Hastings, J.J.; Basha, F.Z.; Hanson, P.R. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-pot Sulfonylation/Thia-Michael Protocol. Heterocycles 2012, 86, 1661-1674. Special Issue Honoring Nobel Laureate Professor Ei-ichi Negishi. Online access to the article.

Zang, Q.; Javed, S.; Zhou, A.; Knudtson, C.A.; Bi, D.; Basha, F.Z.; Hanson, P.R. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles 2012 , 86, 1675-1688. Special Issue Honoring Nobel Laureate Professor Ei-ichi Negishi. Online access to the article.

Chattopadhyay, K.; Fenster, E.; Grenning, A.J.; Tunge, J.A. Palladium-catalyzed substitution of (coumarinyl)methyl-acetates with C-, N- and S-nucleophiles. Beilstein J. Org. Chem. 2012, 8, 1200-1207. Online access to the article.

Faisal, S.; Ullah, F.; Maity, P.K.; Rolfe, A.; Samarakoon, T.B.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Basha, F.Z.; Organ, M.G.; Hanson, P.R. Facile (Triazolyl)methylation of MACOS-derived Benzofused Sultams Utilizing ROMP-derived OTP Reagents. ACS Combi. Sci. 2012, 14(4), 268-272. Online access to the article.

Zang, Q.; Javed, S.; Porubsky, P.; Ullah, F.; Neuenswander, B.; Lushington, G.H.; Basha, F.Z.; Organ, M.G.; Hanson, P.R. Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy ACS Combi. Sci. 2012, 14(3), 211-217. Online access to the article.

Rogness, D.C.; Markina, N.A.; Waldo, J.P.; Larock, R.C. Synthesis of Pyrido[1,2-?]indole Malonates and Amines through Aryne Annulation. Comb. Chem. High Throughput Screening 2012, 77, 2743-2755. Online access to the article.

Fang, Y.; Larock, R.C.; Nucleophilic Addition of 2,3-Pyridyne and Synthesis of Benzonaphthyridinones. Tetrahedron 2012, 68, 2819-2826. Online access to the article.

Lu, C.; Larock, R. C.; Synthesis of 9-Substituted Xanthenes by the Condensation of Arynes with ortho-Hydroxychalcones. Tetrahedron Lett. 2012, 53, 2202-2205. Online access to the article.

Lu, C.; Larock, R. C.; Synthesis of Benzisoxazolines by the Coupling of Arynes with Nitrones. J. Org. Chem. 2012, 77, 2279-2284. Online access to the article.

Markina, N.A.; Dubrovskiy, A.V.; Larock, R.C.; One-pot Synthesis of 1-Alkyl-1H-indazoles from 1,1-Dialkylhydrazones via Aryne Annulation. Org. Biomol. Chem. 2012, 10, 2409-2412. Online access to the article.

Perchellet, J.-P. H.; Waters, A. M.; Perchellet, E. M.; Thornton, P. D.; Brown, N.; Hill, D.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Chandrasoma, N.; Buszek, K. R.; Antitumor Effects of Synthetic 6,7-Annulated-4-Substituted Indole Compounds in L1210 Leukemic Cells in Vitro. Anticancer Res. 2012 , 32, 4671-4684. Online access to the article.

Brown, N.; Buszek, K. R.; Regioselectivity of Diels-Alder Reactions Between 6,7-Dehydrobenzofuran and 2-Substituted Furans. Tetrahedron Lett. 2012, 53, 4022-4025. Online access to the article.

Cho, C.-H.; Shi, F.; Jung, D.-I.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Solution-Phase Synthesis of a Highly Substituted Furan Library. ACS Comb. Sci., 2012, 14, 403-414. Online access to the article.

Fang Y.; Rogness, D. C.; Larock, R. C.; Shi, F. Formation of Acridones by Ethylene Extrusion in the Reaction of Arynes with beta-Lactams and Dihydroquinolinones. J. Org. Chem., 2012, 77, 6262-6270. Online access to the article.

Lu, C.; Dubrovskiy, A. V.; Larock, R. C. Palladium-catalyzed Annulation of Arynes by o-Halobenzamides: Synthesis of Phenanthridinones. J. Org. Chem., 2012, 77, 8648-8656. Online access to the article.

Mehta, S.; Yao, T.; Larock, R. C. Regio- and Stereoselective Synthesis of Cyclic Imidates via Electrophilic Cyclization of 2-(1-Alkynyl)benzamides. A Correction. J. Org. Chem., 2012, 77, 10938-10944. Online access to the article.

Dubrovskiy, A. V.; Larock, R. C. Synthesis of o-(Dimethylamino)aryl Ketones, Acridones, Acridinium Salts, and 1H-Indazoles by the Reaction of Hydrazones and Arynes. J. Org. Chem., 2012, 77, 11232-11256. Online access to the article.

Ullah, F.; Zang, Q.; Javed, S.; Porubsky, P.; Neunswander, B.; Lushington, G.; Hanson, P. R.; Organ, M. G. Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). Synthesis, 2012, 2547–2554. Online access to the article.

Ullah, F.; Zang, Q.; Javed, S.; Zhou, A.; Knudtson, C. A.; Bi. D.; Hanson, P. R.; Organ, M. G. Multi Capillary Flow Reactor: Synthesis of 1,2,5-thiadiazepane 1,1-dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS). J. Flow Chem., 2012, 2, 118–123. Online access to the article.

Zang, Q.; Javed, S.; Hill, D.; Ullah, F.; Porubsky, P.; Neunswander, B.; Lushington, G.; Santini, C.; Organ, M. G.; Hanson, P. R. Automated Synthesis of a Library of Triazolated 1,2,5-Thiadiazepane 1,1-Dioxides via a Double aza-Michael Strategy. ACS Comb. Sci., 2012, 14, 456–459. Online access to the article.

 


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