NIH-National Institute of General Medical Sciences

2009

Wang, C.; Pahadi, N.; Tunge, J. A. Decarboxylative cyclizations and cycloadditions of palladium-polarized aza-ortho-xylylenes. Tetrahedron 2009, 65, 5102-5109. Online access to the article.

Xiaohong W., Smalter, A., Huan, J., Lushington, G. H. G-Hash: Towards Fast Kernel-based Similarity Search in Large Graph Databases. Proceedings of the 12th International Conference on Extending Database Technology (EDBT'09) 2009, 472-480. Online access to the article.

Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; and Tunge, J. A. Formation of N-alkylpyrroles via intermolecular redox amination. J. Am. Chem. Soc. 2009, 131, 16626-16627. Online access to the article.

Jeon, K.; Rayabarapu, D.; Rolfe, A.; Volp, K.; Omar, I.; Hanson, P. R. Metathesis Cascade Strategies (ROM-RCM-CM): A DOS Approach to Skeletally Diverse Sultams. Tetrahedron 2009, 65, 4992-5000. Online access to the article.

Smalter, A.; Huan, J.; Lushington, G. Graph Wavelet Alignment Kernels for Drug Virtual Screening. J. Bioinform. Comput. Biol. 2009, 7, 473-497. Online access to the article.

Brown, N.; Luo, D.; Decapo, J. A.; Buszek, K. R. New Synthesis of (±)-Cis-Trikentrin A via Tandem Indole Aryne Cycloaddition/Negishi Reaction. Applications to Library Development. Tetrahedron Lett. 2009, 50(51), 7113-7115. Online access to the article.

Rolfe, A.; Hanson, P. R. Microwave-assisted Sequential One-pot Protocol to Benzothiadiazin-3-one-1,1-dioxides via a Copper-catalyzed N-Arylation Strategy. Tetrahedron Lett. 2009, 50(50), 6935-3937. Online access to the article.

Worlikar, S. A.; Larock, R. C. Synthesis of 9-Fluorenylidenes and 9,10-Phenanthrenes through Palladium-catalyzed Aryne Annulation by o-Halostyrenes and o-Halo Allylic Benzenes. J. Org. Chem. 2009, 74, 9132-9139. Online access to the article.

Perchellet, J-P.H.; Perchellet, E.M.; Crow, K.R.; Buszek, K.R.; Brown, N.; Ellappan, S.; Gao, G.; Luo, D.; Minatoya, M.; Lushington, G.H. Novel Synthetic Inhibitors of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Activity that Inhibit Tumor Cell Proliferation and are Structurally Unrelated to Existing Statins. Int. J. Mol. Med. 2009, 24(5), 633-643. (Cover Article) Online access to the article.

Ward, T.R.; Turunen, B.J.; Haack, T.; Neuenswander, B.; Shadrick, W.; Georg, G.I. Synthesis of a quinolone library from ynones. Tetrahedron Lett. 2009, 50(47), 6494-6497. Online access to the article.

Chen, Y.; Cho, C.-H.; Shi, F.; Larock, R. C. Synthesis of 3-Sulfenyl- and 3-Selenylindoles by the Pd/Cu-Catalyzed Coupling of N,N-Dialkyl-2-iodoanilines and Terminal Alkynes, Followed by n-Bu4NI-Induced Electrophilic Cyclization. J. Org. Chem. 2009, 74, 6802-6811. Online access to the article.

Jana, R.; Trivedi, R.; Tunge, J. A. Mild Decarboxylative Allylation of Coumarins. Org. Lett. 2009, 11(15), 3434-3436. Online access to the article.

Duan, S.; Jana, R.; Tunge, J. A. Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters. J. Org. Chem. 2009, 74(12), 4612-4614. Online access to the article.

Chen, Y.; Markina, N. A.; Larock, R. C. An Efficient, Microwave-Assisted, One-Pot Synthesis of Indoles Under Sonogashira Conditions. Tetrahedron 2009, 65, 8908-8915. Online access to the article.

Shi, F; Mancuso, R.; Larock, R. C. 1,3-Dipolar Cycloaddition of Arynes with Azomethine Imines: Synthesis of 1,2-Dihydropyrazolo[1,2-a]indazol-3(9H)-ones. Tetrahedron Lett. 2009, 50, 4067-4070. Online access to the article.

Rogness, D.; Larock, R. C. Rapid Synthesis of the Indole-Indolone Scaffold via [3+2] Annulation of Arynes by Methyl Indole-2-carboxylates. Tetrahedron Lett. 2009 , 50, 4003-4008. Online access to the article.

Worlikar, S. A.; Larock, R. C. Palladium-Catalyzed Synthesis of 9-Fluorenylidenes through Aryne Annulation. Org. Lett. 2009, 11(11), 2413-2416. Online access to the article.

Cho, C. H.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Solution-Phase Parallel Synthesis of a Multi-substituted Benzo[b]thiophene Library. J. Comb. Chem. 2009, 11, 900-906. Online access to the article.

Worlikar, S. A.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Highly Substituted Indole Library Synthesis by Palladium-Catalyzed Coupling Reactions in Solution and on a Solid Support. J. Comb. Chem. 2009, 11, 875-879. Online access to the article.

Hershberger, J. C.; Day V. W.; Malinakova, H. C. Diastereoinduction in the Synthesis of Pallada(II)pyrrolidinones: Palladacycles with Two Pd-bonded Stereogenic Carbons. Organometallics 2009, 28(3), 810–818. Online access to the article.

Rolfe, A.; Young, K.; Volp, K.; Schoenen, F. J.; Neuenswander, B.; Lushington, G. H.; Hanson, P. R. One-Pot, Three-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1, 2-benzisothiazoline-3-acetic Acids. J. Comb. Chem. 2009, 11(4), 732-738. Online access to the article.

Rayabarapu, D. K.; Zhou, A.; Jeon, K. O.; Samarakoon, T.; Rolfe, A.; Siddiqui, H.; Hanson, P. R. a-Haloarylsulfonamides: Multiple Cyclization Pathways to Skeletally Diverse Benzofused Sultams. Tetrahedron 2009, 65(16), 3180-3188. Online access to the article.

Thiruvellore, T. J.; Lei, Z.; Johnson, T. S.; Malinakova, H. C. Sequential Cu(I)/Pd(0)-Catalyzed Multicomponent Coupling and Annulation Protocol for the Synthesis of Indenoisoquinolines. Org. Lett. 2009, 11(4), 815-818. Online access to the article.

Zhou, A.; Rayabarapu, D.; Hanson, P. R. Click, Click, Cyclize: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchpins. Org. Lett. 2009, 11(3), 531-534. Online access to the article.

Verma, A. K.; Kesharwani, T.; Singh, J.; Tandon, V.; Larock, R. C. A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines. Angew. Chem, Int. Ed. 2009, 48(6), 1138-1143. Online access to the article.

Mehta, S.; Waldo, J. P.; Larock, R. C. Competition Studies in Alkyne Electrophilic Cyclization Reactions. J. Org. Chem. 2009, 74(3), 1141-1147. Online access to the article.

Buszek, K. R.; Brown, N.; Luo, D. Concise Total Synthesis of (±)-cis-Trikentrin A and (±)-Herbindole A via Intermolecular Indole Aryne Cycloaddition. Org. Lett. 2009, 11(1), 201-204. Online access to the article.

Chen, Y.; Cho, C. H.; Larock, R. C. A Novel Synthetic Route to 3-Sulfenyl- and 3-Selenylindoles by n-Bu4NI-Induced Electrophilic Cyclization. Org. Lett. 2009, 11(1), 173-176. Online access to the article.

Brown, N.; Luo, D.; VanderVelde, D.; Yang, S.; Brassfield, A.; Buszek, K. R. Regioselective Diels-Alder Cycloadditions and Other Reactions of 4,5-, 5,6-, and 6,7-Indole Arynes. Tetrahedron Lett. 2009, 50(1), 63-65. (Cover Article on the 50th Anniversary Cover) Online access to the article.

Roy, S., Roy, S., Neuenswander, B., Hill, D., Larock, R.C. Solution-Phase Synthesis of a Diverse Isocoumarin Library. J. Comb. Chem. 2009 11(6), 1128-1135. Online access to the article.

Roy, S., Roy, S., Neuenswander, B., Hill, D., Larock, R.C. Palladium- and Copper-Catalyzed Solution Phase Synthesis of a Diverse Library of Isoquinolines. J. Comb. Chem. 2009 11(6), 1061-1065. Online access to the article.


48 nationally ranked graduate programs.
—U.S. News & World Report
Pharmacy school No. 2 nationally for NIH funding
Hall Center receives 3rd NEH challenge grant to support humanities research collaboration
Regional leader in technology commercialization
12 graduate programs rank in top 10 nationally among public universities.
—U.S. News & World Report
Driving discovery, innovation, entrepreneurship
Home to 15 major research centers & state surveys
1st in nation for its special education master’s and doctorate programs.
—U.S. News & World Report
1st in nation for its city management and urban policy master’s program.
—U.S. News & World Report
One of 34 U.S. public institutions in the prestigious Association of American Universities
KU Today