NIH-National Institute of General Medical Sciences

2008

 Cho, C. H.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Parallel Synthesis of a Multi-Substituted Benzo[b]furan Library. J. Comb. Chem. 2008, 10(6), 941-947. Online access to the article.

Frankowski, K. J.; Neuenswander, B.; Aubé, J. Explorations of Stemona Alkaloid-Inspired Analogues: Skeletal Modification and Functional Group Diversification. J. Comb. Chem. 2008, 10(5), 721–725. Online access to the article.

Waldo, J. P.; Mehta, S.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. Solution Phase Synthesis of a Diverse Library of Highly Substituted Isoxazoles. J. Comb. Chem. 2008, 10(5), 658-663. Online access to the article.

Rolfe, A.; Probst, D. A.; Volp, K. A.; Omar, I.; Flynn, D. L.; Hanson, P. R. High-load, Oligomeric Dichlorotriazine: A Versatile ROMP-Derived Reagent and Scavenger. J. Org. Chem. 2008, 73(22), 8785-8790. Online access to the article.

Li, K.; Tunge, J. A. Reduction of Pyrrolyl- and Indolylamides with BH3•THF: Cyclodeoxygenation versus Deoxygenation. J. Org. Chem. 2008, 73(21), 8651-8653. Online access to the article.

Worlikar, S. A.; Larock, R. C. Palladium-Catalyzed One Step Synthesis of Isoindole-1,3-diones by Carbonylative Cyclization of o-Halobenzoates and Primary Amines. J. Org. Chem. 2008, 73(18), 7175-7180. Online access to the article.

Shore, G.; Organ, M. G. Gold-film-catalysed hydrosilylation of alkynes by microwave-assisted, continuous flow organic synthesis (MACOS). Chem. Eur. J. 2008, 14(31), 9641-9646. Online access to the article.

Rolfe, A.; Young, K.; Hanson, P. R. Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid. Eur. J. Org. Chem. 2008, 31, 5254 - 5262. Online access to the article.

Gao, G.; Brown, N.; Minatoya, M.; Buszek, K.R. N-Vinylpyridinium tetrafluoroborate salts as reagents for the stereoselective and regioselective synthesis of symmetrical (2E,4E)-1,6-dioxo-2,4-dienes. Tetrahedron Lett. 2008, 49(46), 6491-6494. Online access to the article.

Shore, G.; Organ, M. G. Diels-Alder Cycloadditions by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): The Role of Metal Films in the Flow Tube. Chem. Commun. 2008, 838-840. Online access to the article.

Brown, N.; Xie, B.; Markina, N.; VanderVelde, D.; Perchellet, J.-P. H.; Perchellet, E. M.; Crow, K. R.; Buszek, K. R. Synthesis of a Natural Product-inspired Eight-membered Ring Lactam Library via Ring-closing Metathesis. Bioorg. Med. Chem. Lett. 2008, 18(17), 4876–4879. Online access to the article.

Waldo, J. P.; Zhang, X; Shi, F.; Larock, R. C. Efficient Synthesis of Fluoren-9-ones by the Palladium-Catalyzed Annulation of Arynes by 2-Haloarenecarboxaldehydes. J. Org. Chem. 2008, 73(17), 6679-6685. Online access to the article.

Waldo, J. P.; Mehta, S.; Larock, R. C. Room Temperature ICl-Induced Dehydration/Iodination of 1-Acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles. A Selective Route to Substituted 1-Acyl-4-iodo-1H-pyrazoles. J. Org. Chem. 2008, 73(17), 6666-6670. Online access to the article.

Shore, G.; Morin, S.; Mallik, D.; Organ, M. G. Pd PEPPSI-IPr-Mediated Reactions in Metal-Coated Capillaries Under Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): The Synthesis of Indoles by Sequential Aryl Amination/Heck Coupling. Chem. Eur. J. 2008, 14(4), 1351-1356. Online access to the article.

Aubé, J.; Frankowski, K.; Neuenswander, B. Explorations of Stemona Alkaloid-Inspired Analogues: Skeletal Modification and Functional Group Diversification. J. Comb. Chem. 2008, 10(5), 721–725. Online access to the article.

Brown, N.; Gao, G.; Minatoya, M.; Xie, B.; VanderVelde, D.; Lushington, G. H.; Perchellet, J.-P. H.; Perchellet, E. M.; Crow, K. R.; Buszek, K. R. Design and Synthesis of Medium-Ring Lactam Libraries Inspired by Octalactin A. A Convergent-Divergent Approach. J. Comb. Chem. 2008, 10(5),628–631. Online access to the article.

Poon, K. W. C.; Datta, A. A Rapid Synthetic Route to Conformationally Restricted [5,5]-Bicyclic Nucleoside-Amino Acid Conjugates. Nucleosides, Nucleotides Nucleic Acids 2008, 27(8), 914–930. Online access to the article.

Zhou, A.; Hanson, P. R. Synthesis of Sultam Scaffolds via Intramolecular Oxa-Michael and Diastereoselective Baylis-Hillman Reactions. Org. Lett2008, 10(14), 2951–2954. Online access to the article.

Shi, F.; Waldo, J. P.; Chen, Y.; Larock, R. C. Benzyne Click Chemistry: Synthesis of Benzotriazoles from Benzynes and Azides. Org. Lett2008, 10(12), 2409–2412. Online access to the article.

Stoianova, D. S.; Yao, L.; Rolfe, A.; Samarakoon, T.; Hanson, P. R. High-load, oligomeric monoamine hydrochloride: facile generation via ROM polymerization and application as an electrophile scavenger. Tetrahedron Lett. 2008, 49(29-30), 4553-4555. Online access to the article.

Jiménez-Hopkins, M.; Hanson, P. R. An RCM Strategy to Stereodiverse δ-Sultam Scaffolds. Org. Lett. 2008, 10(11), 2223–2226. Online access to the article.

Frankowski, K. J.; Golden, J. E.; Zeng, Y.; Lei, Y.; Aubé, J. Syntheses of the Stemona Alkaloids (±)-Stenine, (±)-Neostenine, and (±)-13-Epineostenine Using a Stereodivergent Diels-Alder/Azido-Schmidt Reaction. J. Am. Chem. Soc. 2008, 130(18), 6018-6024. Online access to the article.

Stensrud, K. F., Heger, D., Šebej, P., Wirz, J., Givens, R. S. Fluorinated photoremovable protecting groups: The influence of fluoro substituents on the photo-Favorskii rearrangement. Photochem. Photobiol. Sci. 2008, 7(5), 614-624. Online access to the article.

Nöth, J.; Frankowski, K. J.; Neuenswander, B.; Aubé, J.; Reiser, O. Efficient Synthesis of γ-Lactams by a Tandem Reductive Amination/Lactamization Sequence. J. Comb. Chem. 2008, 10(3), 456–459. Online access to the article.

Poon, K. W. C.; Liang, N.; Datta, A. De Novo Synthetic Route to a Combinatorial Library of Peptidyl Nucleosides. Nucleosides, Nucleotides Nucleic Acids 2008, 27(4), 389-407. Online access to the article.

Just, Z. W.; Larock, R. C. Synthesis of 2(3H)-Furanones via Electrophilic Cyclization. J. Org. Chem. 2008, 73(7), 2662-2667. Online access to the article.

Ge, H.; Niphakis, M. J.; Georg, G. I. Palladium(II)-Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates. J. Am. Chem. Soc. 2008, 130(12), 3708-3709. Online access to the article.

Theertham, B.; Wang, J. L.; Fang, J.; Lushington, G. H. Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics. Curr. Comput.-Aided Drug Des. 2008, 4(1), 23-34. Online access to the article.

Givens, R. S.; Heger, D.; Hellrung, B.; Kamdzhilov, Y.; Mac, M.; Conrad, P. G., II; Cope, E.; Lee, J. I.; Mata-Segreda, J. F.; Schowen, R. L.; Wirz, J. The Photo-Favorskii Reaction of p-Hydroxyphenacyl Compounds is Initiated by Water-Assisted, Adiabatic Extrusion of a Triplet Biradical. J. Am. Chem. Soc. 2008, 130(11), 3307-3309. Online access to the article.

Zhang, L.; Lushington, G. H.; Neuenswander, B.; Hershberger, J. C.; Malinakova, H. C. Solution-Phase Parallel Synthesis of Hexahydro-1H-isoindolone Libraries via Tactical Combination of Cu-Catalyzed Three-Component Coupling and Diels-Alder Reactions. J. Comb. Chem. 2008, 10(2), 285-302. Online access to the article.

Fenster, E.; Rayabarapu, D. K.; Zhang, M.; Mukherjee, M.; Hill, D.; Neuenswander, B.; Schoenen, F.; Hanson, P. R.; Aubé, J. Three-Component Synthesis of 1,4-Diazepin-5-ones and the Construction of γ-Turn-like Peptidomimetic Libraries. J. Comb. Chem. 2008, 10(2), 230-234. Online access to the article.

Vedantham, P., Zhang, M., Gor, P. J., Huang, M., Georg, G. I., Lushington, G. H., Mitscher, L. A., Ye, Q.-Z., Hanson, P. R. Studies Towards Synthesis of Methionine Aminopeptidase Inhibitors: Diversification Utilizing a ROMP-Derived Coupling Reagent. J. Comb. Chem. 2008, 10(2), 195-203. Online access to the article.

Vedantham, P.; Guerra, J. M.; Schoenen, F.; Huang, M.; Gor, P. J.; Georg, G. I.; Wang, J. L.; Neuenswander, B.; Lushington, G. H.; Mitscher, L. A.; Ye, Q.-Z.; Hanson, P. R. Ionic Immobilization, Diversification and Release: Application to the Generation of a Library of Methionine Aminopeptidase Inhibitors. J. Comb. Chem. 2008, 10(2), 185-194. Online access to the article.

Smalter, A., Huan, J., Lushington, G. Structure-based Pattern Mining For Chemical Compound Classification. Series on Advances in Bioinformatics and Computational Biology: Proceedings of the 6th Asia Pacific Bioinformatics Conference (APBC) 2008, 6, 39-48.

Li, K.; Tunge, J. A. Chemical Libraries via Sequential C-H Functionalization of Phenols. J. Comb. Chem. 2008, 10(2), 170-174. Online access to the article.

Poon, K. W. C.; Lovell, K. M.; Dresner, K. N.; Datta, A. Trimethylsilyl trifluoromethanesulfonate (TMSOTf) assisted facile deprotection of N,O-acetonides. J. Org. Chem. 2008, 73(2), 752-755. Online access to the article.

Liu, Z.; Shi, F.; Martinez, P. D. G.; Raminelli, C.; Larock, R. C. Synthesis of Indazoles by the [3+2] Cycloaddition of Diazo Compounds with Arynes and Subsequent Acyl Migration. J. Org. Chem. 2008, 73(1), 219-226. Online access to the article.

Fenster, E., Smith, B. T., Gracias, V., Milligan, G. L., and Aubé, J. Nucleophilic Addition to Iminium Ethers in the Preparation of Functionalized N-Alkyl Heterocycles. J. Org. Chem. 2008, 73(1), 201-205. Online access to the article.


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